In this article published December 1, 2011, Doctors Christopher O'Donnell and Elizabeth Nabel review genetic and genomic studies of the past decade which have contributed to our understanding of cardiovascular mechanisms. As the leading cause of death in the United States, cardiovascular disease has been greatly studied, is increasingly understood, and has become much easier to treat. The article addresses alleles at loci associated with heart failure and arrhythmias and considers targeted and genome wide DNA sequencing as applied to cardiovascular medicine. The article thereby delivers a comprehensive overview of recent research in this area through both bottom-up and top-down approaches. Attached also is an interactive timeline, making the material especially accessible.
Pictured: "Genomic Locations of Genetic Variants Associated with the
Risk of Myocardial Infarction and Heart Failure"
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